Tissue cells feel and respond to the stiffness of their substrate.

作者: Dennis E Discher , Paul Janmey , Yu-li Wang

DOI: 10.1126/SCIENCE.1116995

关键词: TranscellularCell signalingBiophysicsTraction force microscopyDurotaxisCell adhesionCancer cellMechanotaxisBiologyCell cultureNanotechnology

摘要: Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid …

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