DNA Methylation and B-Cell Autoreactivity
作者： Soizic Garaud , Pierre Youinou , Yves Renaudineau
DOI: 10.1007/978-1-4419-8216-2_5
关键词: Cancer research 、 CD5 、 DNA 、 Biology 、 Methylation 、 CpG site 、 Gene 、 Cytokine 、 B cell 、 DNA methylation
摘要: Although not exclusive, mounting evidence supports the fact that DNA methylation at CpG dinucleotides controls B-cell development and progressive eliminati or inactivation of autoreactive B cell. Indeed, expression different ce specific factors, including Pax5, rearrangement receptor (BCR) cytokine production are tightly controlled by methylation. Among normal cells, CD5+ cell sub-population presents a reduced capacity to methylate its leads normally repressed genes, such as human endogenous retrovirus (HERV). In systemic lupus erythematosus (SLE) patients, archetype ofautoimmune disease, cells characterized their inability induce prolongs survival. Finally, treating with demethylating drugs increased autoreactivity. Altogether this suggests deeper comprehension ofDNA in may offer opportunities develop new therapeutics control cells.
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