作者: Yuko Nakamura , Marcelino Bernardo , Tadanobu Nagaya , Kazuhide Sato , Toshiko Harada
关键词: Nuclear medicine 、 Imaging biomarker 、 Photoimmunotherapy 、 Magnetic resonance imaging 、 Medicine 、 Area under the curve 、 Cancer 、 Effective diffusion coefficient 、 Gadofosveset 、 Panitumumab
摘要: // Yuko Nakamura 1 , Marcelino Bernardo 2 Tadanobu Nagaya Kazuhide Sato Toshiko Harada Peter L. Choyke Hisataka Kobayashi Molecular Imaging Program, Center for Cancer Research, National Institute, Bethesda, MD, USA Research Technology SAIC-Frederick Inc., Correspondence to: Kobayashi, email: Keywords : near infrared photoimmunotherapy, MRI, T2 relaxation time, diffusion weighted image, gadofosveset Received October 08, 2015 Accepted January 29, 2016 Published February 12, Abstract Near photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies targeting tumors with toxicity induced by photon absorbers after irradiation NIR light. The purpose this study was to determine if MR imaging can detect changes in properties tumor within several hours NIR-PIT. A431 cells were injected subcutaneously right and left dorsi 12 mice. Six days later, mice absorber, IR700, conjugated panitumumab, an antibody epidermal growth factor receptor. One day only sided exposed light (treated tumor). MRI performed before 1-2 NIR-PIT using six gadopentetate dimeglumine another times, apparent coefficient (ADC) following combinations b-values: 0-1000, 200-1000 500-1000 s/mm enhancement indices compared two-sided paired t -test. For treated tumors, time increased (p < 0.01) all three ADC values decreased ( p 0.01). Moreover, area under curve (AUC) = 0.02). In conclusion, prolongation T2, reductions are seen tumors. Thus, be useful biomarker detecting early therapeutic