MR imaging biomarkers for evaluating therapeutic effects shortly after near infrared photoimmunotherapy.

作者: Yuko Nakamura , Marcelino Bernardo , Tadanobu Nagaya , Kazuhide Sato , Toshiko Harada

DOI: 10.18632/ONCOTARGET.7357

关键词: Nuclear medicineImaging biomarkerPhotoimmunotherapyMagnetic resonance imagingMedicineArea under the curveCancerEffective diffusion coefficientGadofosvesetPanitumumab

摘要: // Yuko Nakamura 1 , Marcelino Bernardo 2 Tadanobu Nagaya Kazuhide Sato Toshiko Harada Peter L. Choyke Hisataka Kobayashi Molecular Imaging Program, Center for Cancer Research, National Institute, Bethesda, MD, USA Research Technology SAIC-Frederick Inc., Correspondence to: Kobayashi, email: Keywords : near infrared photoimmunotherapy, MRI, T2 relaxation time, diffusion weighted image, gadofosveset Received October 08, 2015 Accepted January 29, 2016 Published February 12, Abstract Near photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies targeting tumors with toxicity induced by photon absorbers after irradiation NIR light. The purpose this study was to determine if MR imaging can detect changes in properties tumor within several hours NIR-PIT. A431 cells were injected subcutaneously right and left dorsi 12 mice. Six days later, mice absorber, IR700, conjugated panitumumab, an antibody epidermal growth factor receptor. One day only sided exposed light (treated tumor). MRI performed before 1-2 NIR-PIT using six gadopentetate dimeglumine another times, apparent coefficient (ADC) following combinations b-values: 0-1000, 200-1000 500-1000 s/mm enhancement indices compared two-sided paired t -test. For treated tumors, time increased (p < 0.01) all three ADC values decreased ( p 0.01). Moreover, area under curve (AUC) = 0.02). In conclusion, prolongation T2, reductions are seen tumors. Thus, be useful biomarker detecting early therapeutic

参考文章(24)
Shuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Fuminari Uehara, Hiroshi Tazawa, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M. Hoffman, Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma. Oncotarget. ,vol. 6, pp. 13133- 13148 ,(2015) , 10.18632/ONCOTARGET.3811
Shuya Yano, Yukihiko Hiroshima, Ali Maawy, Hiroyuki Kishimoto, Atsushi Suetsugu, Shinji Miwa, Makoto Toneri, Mako Yamamoto, Matthew HG Katz, Jason B Fleming, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman, Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery Cancer Gene Therapy. ,vol. 22, pp. 344- 350 ,(2015) , 10.1038/CGT.2015.26
Shuya Yano, Yong Zhang, Shinji Miwa, Hiroyuki Kishimoto, Yasuo Urata, Michael Bouvet, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M Hoffman, Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus. BMJ Open Respiratory Research. ,vol. 2, pp. 1- 6 ,(2015) , 10.1136/BMJRESP-2015-000096
H C Schwickert, M Stiskal, T P Roberts, C F van Dijke, J Mann, A Mühler, D M Shames, F Demsar, A Disston, R C Brasch, Contrast-enhanced MR imaging assessment of tumor capillary permeability: effect of irradiation on delivery of chemotherapy. Radiology. ,vol. 198, pp. 893- 898 ,(1996) , 10.1148/RADIOLOGY.198.3.8628889
U. Ziegler, P. Groscurth, Morphological features of cell death. Physiology. ,vol. 19, pp. 124- 128 ,(2004) , 10.1152/NIPS.01519.2004
Kazuhide Sato, Rira Watanabe, Hirofumi Hanaoka, Toshiko Harada, Takahito Nakajima, Insook Kim, Chang H. Paik, Peter L. Choyke, Hisataka Kobayashi, Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor. Molecular Oncology. ,vol. 8, pp. 620- 632 ,(2014) , 10.1016/J.MOLONC.2014.01.006
Shuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Michael Bouvet, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M Hoffman, Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus. Molecular Therapy. ,vol. 23, pp. 1182- 1188 ,(2015) , 10.1038/MT.2015.63
Makoto Mitsunaga, Mikako Ogawa, Nobuyuki Kosaka, Lauren T Rosenblum, Peter L Choyke, Hisataka Kobayashi, Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules Nature Medicine. ,vol. 17, pp. 1685- 1691 ,(2011) , 10.1038/NM.2554
V. Tomar, A. Yadav, R.K.S. Rathore, S. Verma, R. Awasthi, V. Bharadwaj, B.K. Ojha, K.N. Prasad, R.K. Gupta, Apparent diffusion coefficient with higher b-value correlates better with viable cell count quantified from the cavity of brain abscess. American Journal of Neuroradiology. ,vol. 32, pp. 2120- 2125 ,(2011) , 10.3174/AJNR.A2674
Kohei Sano, Takahito Nakajima, Peter L. Choyke, Hisataka Kobayashi, Markedly Enhanced Permeability and Retention Effects Induced by Photo-immunotherapy of Tumors ACS Nano. ,vol. 7, pp. 717- 724 ,(2013) , 10.1021/NN305011P