Polymorphism of tumor necrosis factor-α and interleukin-10 gene promoter region in chronic hepatitis C virus patients and their effect on pegylated interferon-α therapy response.

摘要: Abstract The development and resolution of an inflammatory process is regulated by a complex interplay among cytokines that have pro- anti-inflammatory effects. Regulatory mechanisms control the production include genetic polymorphism in particular promoter/leader region. Polymorphisms may directly or indirectly affect binding transcriptional factors, consequently increasing decreasing mRNA, thus regulating cytokine production. A total 70 hepatitis C virus (HCV) RNA–positive patients healthy subjects were included present study, who attending medical outpatient department (OPD) wards tertiary care hospital New Delhi during 2006–2008. This study was designed to determine tumor necrosis factor–α interleukin-10 genes with chronic HCV infection their effect on pegylated interferon–α therapy response. Polymorphism G/G, G/A, A/A genotype significant between controls. Interleukin-10 variants (G/G, G/A) nonsignificant compared As this preliminary small sample size, we believe our findings stimulate further studies larger number from geographic