作者: Thomas Schlange , Birgit Andrée , Hans-Henning Arnold , Thomas Brand
DOI: 10.1016/S0925-4773(00)00454-8
关键词: Lateral plate mesoderm 、 Mesoderm 、 Primitive streak 、 Intermediate mesoderm 、 Somitomere 、 Epiblast 、 Cell biology 、 Biology 、 Genetics 、 NODAL 、 Gastrulation
摘要: Abstract Members of the Cited family are nuclear transactivators which bind to coactivators p300 and CBP. While Cited1 also binds TGFβ signal transducer Smad4, this has not been shown for Cited2. We isolated a chicken homologue Cited2 from HH stage 3–6 cDNA library examined its expression pattern during early stages embryonic development by whole-mount in situ hybridization. CITED2 is detectable epiblast as XI. From 2 onwards expressed an anterior domain elongating primitive streak cells fated become heart. During gastrulation highly dynamic transiently displays left-right asymmetry with stronger on right side. appears at multiple sites forming mesodermal structures. Most prominently, presomitic lateral plate mesoderm, headfold (future forebrain), head pharyngeal floor, ventral blood islands, somitomeres intermediate mesoderm gives rise kidney anlagen.