The successful search for genetic loci associated with depression
作者： Margarita Rivera , Peter McGuffin
DOI: 10.1186/S13073-015-0217-4
关键词: Major depressive disorder 、 Depression (differential diagnoses) 、 Genetic risk 、 Public health 、 Human genetics 、 Genetics 、 Biology 、 Heritability 、 Disease burden 、 Genetic heterogeneity
摘要: Major depressive disorder is among the leading causes of disease burden and disability, as well a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, new study has identified, replicated, two variants associated with an increased for this disorder. The success appears to lie in use low-coverage sequencing, instead microarrays, minimizing phenotypic heterogeneity.
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