The interaction between stress and genetic factors in the etiopathogenesis of depression.

摘要: The presence of a genetic component to depression has been established by family, twin and, lesser extent, adoption studies. Family studies have shown that first-degree relatives patients with on average three times the risk those without family history disorder (1), but at least one study clinically ascertained narrowly defined estimated in siblings be nearly ten controls' (2). A systematic meta-analysis including data from five reported an heritability estimate 37% based provided over 70% (3).