Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.
作者： Joelle Dupont , Derek LeRoith
DOI: 10.1159/000063469
关键词: IRS2 、 Insulin receptor substrate 、 Insulin-like growth factor 1 receptor 、 Insulin-like growth factor 、 Insulin receptor 、 Signal transduction 、 Cell biology 、 Receptor tyrosine kinase 、 Biochemistry 、 GRB10 、 Chemistry
摘要: The insulin receptor (IR) and the insulin-like growth factor I (IGF-IR) belong to same subfamily of tyrosine kinases with two extracellular α-subunits transmembrane β-subunits. They share a high similarity structure intracellular signalling events. However, IR IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis differentiation. Although some variation can be attributed tissue distribution or subcellular localization, it also explained by structural differences in β-subunit, which may result activation specific substrates signal pathways.
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