Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis

作者: Jin Hyen Baek , Jae-Eun Jang , Chang-Mo Kang , Hae-Young Chung , Nam Deuk Kim

DOI: 10.1038/SJ.ONC.1203814

关键词: Receptor tyrosine kinaseBiologyCytochrome cMAPK/ERK pathwayMitogen-activated protein kinaseCarcinogenesisApoptosisCancer researchHypoxia (medical)Signal transduction

摘要: Low oxygen and nutrient depletion play critical roles in tumorigenesis, but little is known about how they interact to produce tumor survival and tumor malignancy. In the present study, …

参考文章(43)
Gregg L. Semenza, Peter H. Roth, Guang L. Wang, Hon Ming Fang, Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. Journal of Biological Chemistry. ,vol. 269, pp. 23757- 23763 ,(1994) , 10.1016/S0021-9258(17)31580-6
A.H. Wyllie, J.F.R. Kerr, A.R. Currie, Cell death : the significance of apoptosis International Review of Cytology-a Survey of Cell Biology. ,vol. 68, pp. 251- 306 ,(1980) , 10.1016/S0074-7696(08)62312-8
Juan Lechago, Mamoun Younes, Jacqueline R. Somoano, Lia V. Lechago, Moni Mosharaf, Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers Cancer Research. ,vol. 56, pp. 1164- 1167 ,(1996)
Constance A. Griffin, Peter L. Pedersen, Anita L. Hawkins, Saroj P. Mathupala, Annette Rempel, Glucose Catabolism in Cancer Cells: Amplification of the Gene Encoding Type II Hexokinase Cancer Research. ,vol. 56, pp. 2468- 2471 ,(1996)
Motohiro Nomura, Sho-ichi Yamagishi, Shin-ichi Harada, Yasuhiko Hayashi, Tetsumori Yamashima, Junkoh Yamashita, Hiroshi Yamamoto, Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes. Journal of Biological Chemistry. ,vol. 270, pp. 28316- 28324 ,(1995) , 10.1074/JBC.270.47.28316
Mohanraj Dhanabal, Ramani Ramchandran, Matthew J. F. Waterman, Hua Lu, Bertrand Knebelmann, Mark Segal, Vikas P. Sukhatme, Endostatin induces endothelial cell apoptosis. Journal of Biological Chemistry. ,vol. 274, pp. 11721- 11726 ,(1999) , 10.1074/JBC.274.17.11721
Manon van Engeland, Luc J.W. Nieland, Frans C.S. Ramaekers, Bert Schutte, Chris P.M. Reutelingsperger, Annexin V‐Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure Cytometry. ,vol. 31, pp. 1- 9 ,(1998) , 10.1002/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R
Andrew H. Wyllie, The genetic regulation of apoptosis Current Opinion in Genetics & Development. ,vol. 5, pp. 97- 104 ,(1995) , 10.1016/S0959-437X(95)90060-8
Pierre A Henkart, ICE Family Proteases: Mediators of All Apoptotic Cell Death? Immunity. ,vol. 4, pp. 195- 201 ,(1996) , 10.1016/S1074-7613(00)80428-8