C-reactive protein, bone loss, fracture, and mortality in elderly women: a longitudinal study in the OPRA cohort.

摘要: Summary This longitudinal study investigates the association between C-reactive protein (CRP), osteoporosis, fractures, and mortality in 1044 elderly women. CRP was not an indi- cator for low bone mineral density (BMD), loss, or fracture women; however, women with elevated levels over a prolonged period lost more 10-year follow-up, although risk increased. Introduction Inflammation may contribute to pathophys- iology underlying impaired metabolism. in- vestigates CRP, BMD, risk, aged 75 above. Methods is based on women, all age at inclusion, reassessed ages 80 85, mean follow-up time of 11.6 years (maximum 16.9 years). Results Women lowest quartile (mean 0.63 mg/L) had lower BMD compared those highest quar- tile(mean5.74mg/L) attotalhip(TH)(0.809vs.0.871g/cm 2 , p<0.001) femoral neck (FN) (0.737 vs. 0.778 g/cm p= 0.007). A singlemeasurement ofCRPwas associatedwith loss; persistently i.e., ≥3 mg/L significantly higher loss <3 (TH −0.125 −0.085 p=0.018 FN −0.127 −0.078 0.005) during 10 follow-up. CRPquartilehadalower riskofosteoporoticfractures(hazard ratios (HR) 0.76 (95 % confidence intervals (CI) 0.52-0.98)) lowest, even after adjusting weight BMD. Mortality only increased among levels. Conclusion indicator this study. Persistently however seemed be detrimental health associated rate loss. Only were mortality.