Gout and the Risk of Non‐vertebral Fracture

摘要: Prior studies suggest an association between osteoporosis, systemic inflammation and pro-inflammatory cytokines such as IL-1 IL-6. Conflicting findings exist on the hyperuricemia osteoporosis. Furthermore, it remains unknown whether gout, a common inflammatory arthritis, affects fracture risk. Using data from US commercial health plan (2004-2013), we evaluated risk of non-vertebral (i.e. forearm, wrist, hip pelvis) in patients with gout versus those without. Gout were identified ≥2 diagnosis codes ≥1 dispensing for gout-related drug. Non-gout patients, visits coded any prescription drugs, free received no drugs. Hip was secondary outcome. Fractures combination procedure codes. Cox proportional hazards models compared non-gout, adjusting over 40 factors osteoporotic fracture. Among baseline serum uric acid (sUA) measurements available, assessed associated sUA. We 73,202 219,606 non-gout matched age, sex, date study entry. The mean age 60 years 82% men. Over 2-year follow-up, incidence rate per 1,000 person-years 2.92 2.66 non-gout. adjusted hazard ratio (HR) 0.98 (95%CI 0.85-1.12) 0.83 0.65-1.07) Subgroup analysis (n = 15,079) showed sUA (HR 1.03, 95%CI 0.93-1.15), comorbidity score number not This article is protected by copyright. All rights reserved