Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration

摘要: Abstract Intracranial electroencephalography (iEEG) is clinically indicated for medically refractory epilepsy and a promising approach developing neural prosthetics. These recordings also provide valuable data cognitive neuroscience research. Accurate localization of iEEG electrodes essential evaluating specific brain regions underlying the that indicate normal or pathological activity, as well relating research findings to neuroimaging lesion studies. However, are frequently tucked underneath edge craniotomy, inserted via burr hole, placed deep within brain, where their locations cannot be verified visually with neuronavigational systems. We show one existing method, registration postimplant computed tomography (CT) preoperative magnetic resonance imaging (MRI), can result in errors exceeding 1 cm. present novel method localizing using routinely acquired surgical photographs, X-ray radiographs, scans. Known control points used compute projective transforms link different image sets, ultimately allowing hidden localized, addition refining location manually registered visible electrodes. As technique does not require any calibration between modalities, it applied databases. The final set electrode positions on patient’s rendered MRI yielding relative sulcal gyral landmarks individual anatomy, MNI coordinates. demonstrate results our eight patients implanted grids spanning left hemisphere.