Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.
作者： Jiekun Xuan , Si Chen , Baitang Ning , William H. Tolleson , Lei Guo
DOI: 10.1016/J.CBI.2015.10.009
关键词: Drug 、 Toxicity 、 Pharmacology 、 Biology 、 Metabolism 、 Enzyme 、 Liver injury 、 Drug metabolism 、 Cell culture 、 Chlorpromazine
摘要: … , the enzymatic activities of representative CYPs in the corresponding cell lines were also measured. Using our CYP-expressed HepG2 … Similar expression pattern was observed in three …
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