Lmx1b, Pet-1, and Nkx2.2 Coordinately Specify Serotonergic Neurotransmitter Phenotype
作者： Leping Cheng , Chih-Li Chen , Ping Luo , Min Tan , Mengsheng Qiu
DOI: 10.1523/JNEUROSCI.23-31-09961.2003
关键词: Phenotype 、 Regulation of gene expression 、 Hindbrain 、 Transcription Factor Gene 、 Brainstem 、 Homeobox 、 Neuroscience 、 Biology 、 Serotonergic 、 Ectopic expression
摘要: Serotonergic (5-HT) neurons in the brainstem modulate a wide range of physiological processes and behaviors. Two transcription factor genes, Pet-1 Nkx2.2, are necessary but not sufficient to specify 5-HT transmitter phenotype. Here we show that Lim class homeobox gene Lmx1b is required for proper formation entire system hindbrain, as indicated by loss expression genes serotonin synthesis transport null mice. Pet1 act downstream their independently regulated at time when phenotype specified. Ectopic plus able induce cells most ventral spinal cord, where Nkx2.2 normally expressed. Combined all three Lmx1b, Pet-1, drives differentiation dorsal cord. Our studies therefore define molecular pathway serotonergic neurotransmitter
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