Biological response of human bone marrow stromal cells to sandblasted titanium nitride-coated implant surfaces.
作者： Marco Annunziata , Luigi Guida , Letizia Perillo , Raffaella Aversa , Irene Passaro
DOI: 10.1007/S10856-008-3514-2
关键词: Materials science 、 Biomedical engineering 、 Viability assay 、 Osteocalcin 、 Implant 、 Alkaline phosphatase 、 Titanium nitride 、 Stromal cell 、 Titanium 、 Dentistry 、 Scanning electron microscope
摘要: Titanium nitride (TiN) coating has been proposed as an adjunctive surface treatment aimed to increase the physico-mechanical and aesthetic properties of dental implants. In this study we investigated biological response primary human bone marrow stromal cells (BMSC) TiN-coated sandblasted (TiN-SB) compared uncoated (SB) surfaces. SB TiN-SB disks were qualitatively quantitatively analyzed by atomic force microscopy. BMSC obtained from healthy donors their adhesion proliferation on titanium evaluated scanning electron microscopy viability assay. The osteoblastic differentiation, in terms alkaline phosphatase activity, osteocalcin synthesis, extracellular mineralization, was assessed specific immunoenzymatic or spectrophotometric assays. No difference (P > 0.05) between found any parameters. TiN-coating showed maintain topographical characteristics surfaces affinity toward precursors.
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