A novel double-layered polymeric nanofiber-based dressing with controlled drug delivery for pain management in burn wounds

摘要: Localized application of drugs at specific wound area has many advantages and less side effects as compared with other drug administrative routes. Burn patients suffer from swear pain, the major focus medical practitioners includes pain infection management. Advancements in material science, especially nanofibers, have gained a lot attention various applications such filtration, nanocomposites, protection sciences. Nanofibers (NFs) loaded drug, applied on local area, can reduce well provide quick action. This study dealt fabrication drug-loaded NFs for better management controlled release. Two layers were fabricated different using electrospinning. Contact layer polyethylene oxide nanofibers was gabapentin (a nerve killer) action followed by second sodium alginate acetaminophen (mild synergizing effect. The dressing characterized scanning electron microscope, Fourier transform infrared spectroscopy, thermogravimetric analysis, UV–Vis release rate liquid absorption tests. Different kinetic models to experimental data, first best first-order model, while, described Hixson–Crowell model. combination strong killer slow mild could be good tool scores more professional manner burn patients.