Clinicopathological aspects of mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland: a retrospective single-center analysis of 28 cases.
作者： Marlene Troch , Michael Formanek , Berthold Streubel , Leonhard Müllauer , Andreas Chott
DOI: 10.1002/HED.21533
关键词: Parotid gland 、 Pathology 、 Trisomy 、 Medicine 、 Interquartile range 、 Mucosa-associated lymphoid tissue 、 MALT lymphoma 、 Lymphoma 、 Stage (cooking) 、 Autoimmune disease
摘要: Background. In constrast to its gastric counterpart, mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland has not been studied extensively. We analyzed clinicopathological features and clinical course all patients with MALT diagnosed treated at our institution. Methods. Patient characteristics including an underlying autoimmune disease, disease stage, genetic aberrations, treatment, were assessed evaluated. Twenty-eight (19 women, 9 men) identified; median age diagnosis was 49 years (interquartile range [IQR], 40–56), 18 (64%) had disease. Eleven stage IE, 7 IIE, 10 advanced (stage IV). Results. Genetic aberrations detected in 20 patients; 5 trisomy 3, 2 a t(11;18)(q21;21) translocation, 1 3 18, patient t(14;18)(q32;q21) translocation plus 18. After follow-up time 62 months (IQR, 32–98 months), 24 (86%) are alive. Fifteen free from lymphoma, whereas 13 (46%) have relapse. Conclusion. Our data suggest that is often associated diseases most common feature this The high rate relapse warrants further study on optimal therapy such patients. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
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