Electrochemotherapy in Veterinary Oncology

摘要: Electropermeabilization is a method that uses electric field pulses to induce an electrically mediated reorganization of the plasma membrane cells. Electrochemotherapy combines local or systemic administration chemotherapeutic drugs such as bleomycin cisplatin have poor permeability with electropermeabilization by direct application tumors. Preclinical studies demonstrated excellent antitumor effectiveness electrochemotherapy on different animal models and various tumor types, minimal toxicity, safety procedure. Based results preclinical studies, clinical were conducted in human patients, which pronounced 80-85% objective responses treated cutaneous SC Clinical veterinary oncology very effective treatment tumors histologic types cats, dogs, horses. The these also approximately 80% long-lasting electrochemotherapy. Primary treated. has future promise be highly effective, could used treat primary recurrent solitary multiple histology adjuvant surgery.