METABOLIC TRANSFORMATION SHAPES POLYCHLORINATED BIPHENYL AND POLYBROMINATED DIPHENYL ETHER PATTERNS IN BELUGA WHALES (DELPHINAPTERUS LEUCAS)
作者： Jean-Pierre W. Desforges , Peter S. Ross , Lisa L. Loseto
DOI: 10.1002/ETC.2164
关键词: Polychlorinated biphenyl 、 Zoology 、 Chemistry 、 Congener 、 Beluga 、 Persistent organic pollutant 、 Monodontidae 、 Whale 、 Ecology 、 Cetacea 、 Beluga Whale 、 Health, Toxicology and Mutagenesis 、 Environmental chemistry
摘要: While the accumulation of persistent contaminants in marine mammals can be attributed directly to their prey, role metabolism shaping patterns is often overlooked. In present study, authors investigated metabolic transformation influencing polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) offshore nearshore groups beluga whales (Delphinapterus leucas) prey. Congener profiles principal components analysis (PCA) revealed similar PCB PBDE feeding either or nearshore, despite divergent contaminant putative prey these two groups. The clustering PCBs into metabolically derived structure-activity (SAGs) separation metabolizable recalcitrant along component 1 PCA important beluga. Lack for congeners with high ortho-chlorine content was by slopes equal greater than 1.0. Metabolic all other SAGs were less 1.0 (p<0.001), suggesting ortho-meta meta-para vicinal hydrogens via induction cytochrome P450 enzymes (CYP1A/2B/3A). indices PBDEs (p<0.001) suggested that metabolized poorly understood flame retardants. strikingly a captive free-ranging from Beaufort Sea provide additional evidence dominant driver
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