A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development.
作者： B. J. S. Efiok , J. A. Chiorini , B. Safer
DOI: 10.1016/S0021-9258(17)32255-X
关键词: Biology 、 Eukaryotic transcription 、 Sp3 transcription factor 、 TAF2 、 General transcription factor 、 TCF4 、 E-box 、 Genetics 、 Promoter 、 Response element
摘要: In response to growth, metabolic, and other signals, eukaryotic cells regulate protein biosynthesis through post-translational mechanisms which target the alpha subunit of initiation factor-2 (eIF-2 alpha). Previous efforts study transcriptional underlying this regulation identified a novel transcription factor (alpha-Pal) for eIF-2 gene. To gain insights into overall biological function alpha-Pal, we cloned its cDNA. Sequence analysis encoded reveals that alpha-Pal is putative bZIP factor. Surprisingly, both sequence DNA-recognition site (TGCGCATGCGCA) human are strongly homologous those two evolutionarily distant developmental factors, P3A2 ewg. Since directs territory-specific muscle genes in sea urchin embryos, ewg apparently flight neuronal Drosophila it likely similar gene during embryogenesis. studies, also containing alpha-Pal-binding sequences as involved cellular proliferation, or growth-responsive metabolic pathways, energy transduction, translation, DNA replication/repair. Such data suggest functions modulate required growth.
sci-hub.st 参考文章(46)
ROSEMARY JAGUS, D. CROUCH, A. KONIECZNY, B. SAFER, The role of phosphorylation in the regulation of eukaryotic initiation factor 2 activity. Current Topics in Cellular Regulation. ,vol. 21, pp. 35- 63 ,(1982) , 10.1016/B978-0-12-152821-8.50006-2
R. B. Cohen, T. R. Boal, B. Safer, Increased eIF-2 alpha expression in mitogen-activated primary T lymphocytes. The EMBO Journal. ,vol. 9, pp. 3831- 3837 ,(1990) , 10.1002/J.1460-2075.1990.TB07601.X
Rosemary Jagus, W. French Anderson, Brian Safer, The regulation of initiation of mammalian protein synthesis. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 25, pp. 127- 185 ,(1981) , 10.1016/S0079-6603(08)60484-5
C.M. Chau, M.J. Evans, R.C. Scarpulla, Nuclear respiratory factor 1 activation sites in genes encoding the gamma-subunit of ATP synthase, eukaryotic initiation factor 2 alpha, and tyrosine aminotransferase. Specific interaction of purified NRF-1 with multiple target genes. Journal of Biological Chemistry. ,vol. 267, pp. 6999- 7006 ,(1992) , 10.1016/S0021-9258(19)50527-0
R Duncan, J W Hershey, Regulation of initiation factors during translational repression caused by serum depletion. Abundance, synthesis, and turnover rates. Journal of Biological Chemistry. ,vol. 260, pp. 5486- 5492 ,(1985) , 10.1016/S0021-9258(18)89048-2
W.F. Jacob, T.A. Silverman, R.B. Cohen, B Safer, Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2α Journal of Biological Chemistry. ,vol. 264, pp. 20372- 20384 ,(1989) , 10.1016/S0021-9258(19)47073-7
R Duncan, J W Hershey, Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. Journal of Biological Chemistry. ,vol. 260, pp. 5493- 5497 ,(1985) , 10.1016/S0021-9258(18)89049-4
J.H. De Winde, L.A. Grivell, Global Regulation of Mitochondrial Biogenesis in Saccharomyces cerevisiae Progress in Nucleic Acid Research and Molecular Biology. ,vol. 46, pp. 51- 91 ,(1993) , 10.1016/S0079-6603(08)61018-1
J.A. Chiorini, T.R. Boal, S. Miyamoto, B. Safer, A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta Journal of Biological Chemistry. ,vol. 268, pp. 13748- 13755 ,(1993) , 10.1016/S0021-9258(18)86920-4
I Mikaélian, E Drouet, V Marechal, G Denoyel, J C Nicolas, A Sergeant, The DNA-binding domain of two bZIP transcription factors, the Epstein-Barr virus switch gene product EB1 and Jun, is a bipartite nuclear targeting sequence. Journal of Virology. ,vol. 67, pp. 734- 742 ,(1993) , 10.1128/JVI.67.2.734-742.1993