A General Method to Correct PET Data for Tissue Metabolites Using a Dual-Scan Approach
作者： Jeffrey T. Yap , Vincent J. Cunningham , Pat Price , Roger N. Gunn , Paula Wells
DOI:
关键词: Chemistry 、 Time course 、 Subtraction 、 Biomedical engineering 、 Metabolite 、 Kinetic analysis 、 Pulse response 、 Nuclear medicine 、 General method
摘要: UNLABELLED This article presents and analyses a general method of correcting for the presence radiolabeled metabolites from parent radiotracer in tissue during PET scanning. The is based on dual-scan approach, i.e., scan together with an independent supplementary which metabolite interest itself administered. corrects systemically derived delivered to tissues through blood. METHODS Data are analyzed obtain impulse response function metabolite. time course plasma convolved its derive correction term. not simple subtraction technique but 1 that takes account different time-activity curves 2 scans. RESULTS method, implications, limitations discussed respect [11C]thymidine principal 11CO2. CONCLUSION can be used correct accounts
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