Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography.
作者： V BUSIGNIES , B LECLERC , P PORION , P EVESQUE , G COUARRAZE
DOI: 10.1016/J.EJPB.2006.02.007
关键词: Analytical chemistry 、 Porosity 、 Dosage form 、 X-ray microtomography 、 Brinell scale 、 Materials science 、 Compaction 、 Calibration curve 、 Microcrystalline cellulose 、 Calibration
摘要: Abstract Direct compaction is a complex process that results in density distribution inside the tablets which often heterogeneous. Therefore, variations may affect compact properties. A quantitative analysis of this phenomenon still lacking. Recently, X-ray microtomography has been successfully used pharmaceutical development to study qualitatively impact tablet shape and break-line tablets. In study, we evaluate profile microcrystalline cellulose (Vivapur 12®) compacts obtained at different mean porosity (ranging from 7.7% 33.5%) using tomography technique. First, validity Beer–Lambert law studied. Then, calibration performed maps cylindrical are visualized with colour-scale plot explained. As expected, important heterogeneity observed quantified. The higher densities peripheral region were particularly investigated appraised regard lower middle tablet. also underlined case tablets, it differentiate mechanical properties representative total volume only characterize surface like Brinell hardness measurements.
archives-ouvertes.fr
elsevier.com
sci-hub.se 参考文章(16)
EUGENE RYSHKEWITCH, Compression Strength of Porous Sintered Alumina and Zirconia Journal of the American Ceramic Society. ,vol. 36, pp. 65- 68 ,(1953) , 10.1111/J.1151-2916.1953.TB12837.X
İsmail Aydin, Brian J. Briscoe, Kenan Y. Şanlitürk, The internal form of compacted ceramic components: a comparison of a finite element modelling with experiment Powder Technology. ,vol. 89, pp. 239- 254 ,(1996) , 10.1016/S0032-5910(96)03188-9
H.M. Macleod, U. Marshall, The determination of density distribution in ceramic compacts using autoradiography Powder Technology. ,vol. 16, pp. 107- 122 ,(1977) , 10.1016/0032-5910(77)85028-6
L Salvo, P Cloetens, E Maire, S Zabler, J.J Blandin, J.Y Buffière, W Ludwig, E Boller, D Bellet, C Josserond, X-ray micro-tomography an attractive characterisation technique in materials science Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms. ,vol. 200, pp. 273- 286 ,(2003) , 10.1016/S0168-583X(02)01689-0
Virginie Busignies, Pierre Tchoreloff, Bernard Leclerc, Christine Hersen, Gérard Keller, Guy Couarraze, Compaction of crystallographic forms of pharmaceutical granular lactoses. II. Compacts mechanical properties European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 58, pp. 577- 586 ,(2004) , 10.1016/J.EJPB.2004.04.005
I.C. Sinka, S.F. Burch, J.H. Tweed, J.C. Cunningham, Measurement of density variations in tablets using X-ray computed tomography. International Journal of Pharmaceutics. ,vol. 271, pp. 215- 224 ,(2004) , 10.1016/J.IJPHARM.2003.11.022
V. Busignies, P. Tchoreloff, B. Leclerc, M. Besnard, G. Couarraze, Compaction of crystallographic forms of pharmaceutical granular lactoses. I. Compressibility. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 58, pp. 569- 576 ,(2004) , 10.1016/J.EJPB.2004.04.007
G. Nebgen, D. Gross, V. Lehmann, F. Müller, 1H‐NMR Microscopy of Tablets * Journal of Pharmaceutical Sciences. ,vol. 84, pp. 283- 291 ,(1995) , 10.1002/JPS.2600840304
Leon Farber, Gabriel Tardos, James N. Michaels, Use of X-ray tomography to study the porosity and morphology of granules Powder Technology. ,vol. 132, pp. 57- 63 ,(2003) , 10.1016/S0032-5910(03)00043-3
I.C Sinka, J.C Cunningham, A Zavaliangos, The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: a validation study of the Drucker–Prager Cap model Powder Technology. ,vol. 133, pp. 33- 43 ,(2003) , 10.1016/S0032-5910(03)00094-9