Pak protein kinases and their role in cancer.
作者： Bettina Dummler , Kazufumi Ohshiro , Rakesh Kumar , Jeffrey Field
DOI: 10.1007/S10555-008-9168-1
关键词: p21-activated kinases 、 Cdc42 GTP-Binding Protein 、 Cancer cell 、 Rac GTP-Binding Proteins 、 Cell growth 、 CDC42 、 Cell biology 、 Cancer research 、 Kinase 、 Biology 、 Cytoskeleton
摘要: Some of the characteristics cancer cells are high rates cell proliferation, survival, and ability to invade surrounding tissue. The cytoskeleton has an essential role in these processes. Dynamic changes necessary for motility dependent on invasion metastasis. signaling pathways behind reshaping migrating properties involve a group Ras-related small GTPases their effectors, including p21-activated kinases (Paks). Paks family serine/threonine protein comprised six isoforms (Pak 1-6), all which direct targets Rac Cdc42. Besides cytoskeletal dynamics, have recently been shown regulate various other cellular activities, mitosis, transcription. overexpressed and/or hyperactivated several human tumors transformation makes them attractive therapeutic targets. Pak-targeted therapeutics may efficiently inhibit certain types efforts identify selective Pak-inhibitors underway.
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