Improved prognosis for granulocytopenic patients with gram-negative bacteremia

摘要: Abstract The grave prognosis associated with gram-negative bacteremia occurring in granulocytopenic patients cancer suggests that granulocyte transfusions are frequently indicated. We have evaluated 67 episodes of bacteremia, studied four consecutive antibiotic trials, order to correlate prognostic determinants recovery. These had a median absolute count 100/μl at the time bacteremia. Empiric regimens were begun first evidence suspected infection. Granulocyte employed only as clinically indicated by inadequate patient response therapy. Among 29 who an increase their ⩾100/μl over subsequent 14 days, 27 (93 per cent) recovered whereas among 38 no appreciable count, 21 (55 improved (p = 0.006). In this latter group recovery, susceptibility pathogen(s) initial empiric regimen was major importance. None responded when pathogen resistant both antibiotics initially utilized, six (44 there one antibiotic, and 15 20 (75