Clinical experience with transfusion of granulocytes obtained by continuous flow filtration leukopheresis.

摘要: Abstract Granulocytes obtained by continuous flow filtration leukopheresis (CFFL) were transfused to 21 patients on 131 occasions. An average of 28.2 × 10 9 granulocytes administered per transfusion. These cells more than 90 cent viable dye exclusion, ingested latex particles normally and had almost normal bactericidal activity. Migration skin windows was demonstrated four six attempts, but 51 Cr-labeling studies failed show localization in infected areas Post-transfusion granulocyte count increments averaged 225/μl transient. Significant transfusion reactions occurred during 35 transfusions 13 patients. Reactions some without demonstrable alloimmunization after infusions HL-A identical or compatible cells. Definite clinical improvement noted three recipients. Stabilization infection with patient survival nine times, progression death eight times. CFFL are functional. Their is not risk must still be considered an investigative procedure suggestive as yet unproved efficacy.