Four human carcinoma cell lines with novel mutations in position 12 of c-K- ras oncogene
作者： D. M. Valenzuela , J. Groffen
DOI: 10.1093/NAR/14.2.843
关键词: Oligonucleotide 、 Cell culture 、 Biology 、 DNA 、 Molecular biology 、 Mutation 、 Oncogene 、 Gene 、 Nucleic acid thermodynamics 、 Carcinoma
摘要: We have used synthetic oligonucleotides to probe for mutations affecting amino acid 12 of the c-K-ras gene in human cell line DNA. Of seven carcinoma lines tested, four were found contain a mutation at this position. In each nucleotide G was replaced with an A resulting Gly Asp substitution three cases (cell A427, A1165 and A1663) Ser fourth (A549). Neither these substitutions been previously reported either tumor or tumor-derived DNA's. These results indicate that association between involving position oncogene carcinomas may be stronger than recognized.
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