IMPACT OF RED BLOOD CELL TRANSFUSION ON GLOBAL AND REGIONAL MEASURES OF OXYGENATION

摘要: Anemia is common in critically ill patients. While the goal of transfusion red blood cells (RBCs) to increase oxygen carrying capacity, there are contradictory results about whether RBC treat moderate anemia (e.g. hemoglobin 7–10 g/dL) improves tissue oxygenation or changes outcomes. increasing levels eventually lead a level critical delivery (DO2), increased cardiac output and extraction homestatic mechanisms body uses prevent state dysoxia setting diminished DO2 due anemia. In order for face anemia, normovolemia must be maintained. Transfusion RBCs increases viscosity which may actually decrease (barring hypovolemia prior transfusion). Studies have generally shown that fails uptake (VO2) unless VO2/DO2 dependency exists, e.g., severe strenuous exercise. Recently near-infrared spectroscopy (NIRS), approximates saturation venous blood, has been used investigate NIRS measurements regional beds (e.g., brain, peripheral skeletal muscle). These studies derived following transfusion. evaluating effect on microcirculation functional capillary density. This article will review fundamental aspects extraction, effects as well microcirculation.