In Vivo and in Vitro Binding of IgA to the Plasma Membrane of Hepatocytes

摘要: IgA bound in vivo was shown by immunofluorescence on the plasma membrane of isolated hepatocytes from subjects with normal liver and patients cirrhosis, chronic active hepatitis or fatty liver. sera elevated concentrations, especially cases alcoholic vitro to rabbit mouse. This not due high concentration per se. Moreover, polyclonal polymeric serum-type secretory IgA, three ten monoclonal preparations, showed similar binding properties. Conversely, purified monemeric did show affinity for hepatocytes. The seem depend proportion dimers larger polymers, kappa- lambda-type light chains, heavy-chain subclasses, content J chain secetory component. is probably a physiological phenomenon which part may explain clearance serum.