An assessment of regeneration across peripheral nerve allografts in rats receiving short courses of cyclosporin A immunosuppression.

摘要: Abstract While peripheral nerve reconstruction could benefit from the use of allografts, long term immunosuppression for non-vital organ transplantation is controversial. This study investigated effectiveness short course Cyclosporin A immunosuppression. Fourteen Lewis (RTl 1 ) rats were recipients 3 cm sciatic grafts ACI a donors, repaired to transected recipient animal. Animals treated with (5 mg/kg/day) eight weeks. Neuromuscular function was assessed every two weeks by index determinations until 20 Electrophysiological, histological and morphological evaluations performed at 14 ( n = 6 8) postengraftment. Rats had significantly improving functional studies four P 0.01). Function decreased following cessation treatment. evaluated evidence graft rejection inflammatory cell infiltration, extensive demyelination remyelination, some Wallerian degeneration. demonstrated improvement in parameters motor after engraftment. In this allograft model, immunosuppression, although resulting an initial episode rejection, successful permitting good regeneration neuromuscular function.