Raf Family Kinases: Old Dogs Have Learned New Tricks

作者: D. Matallanas , M. Birtwistle , D. Romano , A. Zebisch , J. Rauch

DOI: 10.1177/1947601911407323

关键词: Cell biologyCancerSignal transductionASK1KinaseCancer developmentEffectorDrug developmentBiologyMAPK/ERK pathway

摘要: First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the objects of intense research. The discoveries 10 years later that the Raf family members (Raf …

参考文章(429)
S.J. Cook, B. Rubinfeld, I. Albert, F. McCormick, RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. The EMBO Journal. ,vol. 12, pp. 3475- 3485 ,(1993) , 10.1002/J.1460-2075.1993.TB06022.X
R. Marais, Y. Light, H.F. Paterson, C.J. Marshall, Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal. ,vol. 14, pp. 3136- 3145 ,(1995) , 10.1002/J.1460-2075.1995.TB07316.X
Véronique Le Mellay, Jakob Troppmair, Roland Benz, Ulf R Rapp, Negative regulation of mitochondrial VDAC channels by C-Raf kinase BMC Cell Biology. ,vol. 3, pp. 14- 14 ,(2002) , 10.1186/1471-2121-3-14
Pablo Rodriguez‐Viciana, Katherine A. Rauen, Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome. Methods in Enzymology. ,vol. 438, pp. 277- 289 ,(2008) , 10.1016/S0076-6879(07)38019-1
I.C. Northwood, F.A. Gonzalez, M. Wartmann, D.L. Raden, R.J. Davis, Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669 Journal of Biological Chemistry. ,vol. 266, pp. 15266- 15276 ,(1991) , 10.1016/S0021-9258(18)98612-6
Dan Li, Jian Ding, Xiaozhong Wang, Chengdang Wang, Ting Wu, Fibronectin promotes tyrosine phosphorylation of paxillin and cell invasiveness in the gastric cancer cell line AGS. Tumori. ,vol. 95, pp. 769- 779 ,(2009) , 10.1177/030089160909500621
James A. McCubrey, William L. Blalock, John G. Shelton, Linda S. Steelman, Richard Franklin, Patrick M. Navolanic, John T. Lee, Fumin Chang, Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review) International Journal of Oncology. ,vol. 22, pp. 469- 480 ,(2003) , 10.3892/IJO.22.3.469
Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0
Guri Tzivion, Zhijun Luo, Joseph Avruch, A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity Nature. ,vol. 394, pp. 88- 92 ,(1998) , 10.1038/27938
Min Suk Shim, Young Jik Kwon, Efficient and targeted delivery of siRNA in vivo. FEBS Journal. ,vol. 277, pp. 4814- 4827 ,(2010) , 10.1111/J.1742-4658.2010.07904.X