Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
作者： Davide F.V. Corona , John W. Tamkun
DOI: 10.1016/J.BBAEXP.2003.09.018
关键词: HMG-box 、 Chromatin remodeling 、 Transcription factor 、 Chromatin 、 Origin recognition complex 、 DNA replication 、 Biology 、 Control of chromosome duplication 、 Nucleosome 、 Genetics
摘要: ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use energy ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating access transcription factors other regulatory proteins DNA. Here we discuss recent progress toward understanding biological ISWI, with an emphasis on its roles in transcription, chromosome organization DNA replication.
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