Clinical and bacteriological study of nosocomial infections due to Enterobacter aerogenes resistant to imipenem.

摘要: Abstract Enterobacter aerogenes strains resistant to imipenem were isolated in 10 patients, 7 of whom had received imipenem-cilastatin. The differentiated by biotype, antibiotype, and plasmid content. All the overproduced a chromosomal cephalosporinase lost major outer membrane protein with size about 40 kDa. In 5 E. extended-spectrum cephalosporin during same stay. three similarity between imipenem-susceptible -resistant suggests occurrence mutation reversion vivo. combination imipenem-cilastatin has been critically important for use multiresistant Enterobacter spp., but its increases risk selection imipenem-resistant strains.