Evolution of oncolytic viruses

摘要: Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies. On other hand, evolution be directed in laboratory create more potent safer OVs. Previous work experimental field provides a background for evolution, has identified interesting exploitable features. While genetic engineering greatly advanced virotherapy, this approach is sometimes curtailed by complexity diversity virus-host interactions. Directed an alternative that help obtain new OVs without prejudice toward underlying molecular mechanisms involved.