Exogenous tyrosol inhibits planktonic cells and biofilms of Candida species and enhances their susceptibility to antifungals.
作者： Rossana de A Cordeiro , Carlos EC Teixeira , Raimunda SN Brilhante , Débora SCM Castelo-Branco , Lucas P Alencar
关键词: Corpus albicans 、 Tyrosol 、 Candida albicans 、 Biology 、 Hypha 、 Broth microdilution 、 Microbiology 、 Amphotericin B 、 Biofilm 、 Ergosterol
摘要: Tyrosol is a quorum-sensing molecule of Candida albicans able to induce hyphal development in the early and intermediate stages biofilm growth. In present study, we evaluated effect high concentrations exogenous tyrosol on planktonic cells biofilms C. (n = 10) tropicalis 10), investigated whether could be synergic antifungals that target cellular ergosterol. Antifungal susceptibility drug interaction against were by broth microdilution method. was inhibit cells, with MIC values ranging from 2.5 5.0 mM for both species. Synergism observed between tyrosol/amphotericin B (11/20 strains), tyrosol/itraconazole (18/20 strains) tyrosol/fluconazole strains). Exogenous alone or combined at 10 × 50 reduce Mature susceptible amphotericin MIC. On other hand, plus azoles enhanced
oup.com
oxfordjournals.org
sci-hub.se 参考文章(50)
F J Cabañes, Yeast Pathogens of Domestic Animals Springer, Berlin, Heidelberg. pp. 253- 279 ,(2010) , 10.1007/978-3-642-03150-2_12
GS De Hoog, J Guarro, J Gené, SA Ahmed, AMS Al-Hatmi, MJ Figueras, RG Vitale, Atlas of Clinical Fungi ,(2000)
Raimunda SN Brilhante, Manoel AN Paiva, Célia MS Sampaio, Carlos EC Teixeira, Débora SCM Castelo-Branco, João JG Leite, Camila A Moreira, Liliane P Silva, Rossana A Cordeiro, André J Monteiro, José JC Sidrim, Marcos FG Rocha, None, Yeasts from Macrobrachium amazonicum: a focus on antifungal susceptibility and virulence factors of Candida spp. FEMS Microbiology Ecology. ,vol. 76, pp. 268- 277 ,(2011) , 10.1111/J.1574-6941.2011.01050.X
Sónia Silva, Melyssa Negri, Mariana Henriques, Rosário Oliveira, David W. Williams, Joana Azeredo, Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance Fems Microbiology Reviews. ,vol. 36, pp. 288- 305 ,(2012) , 10.1111/J.1574-6976.2011.00278.X
Catherine L. Rogers, Christopher Gibson, Susan L. Mitchell, John H. Keating, Elizabeth A. Rozanski, Disseminated candidiasis secondary to fungal and bacterial peritonitis in a young dog. Journal of Veterinary Emergency and Critical Care. ,vol. 19, pp. 193- 198 ,(2009) , 10.1111/J.1476-4431.2009.00405.X
M. Tumbarello, B. Posteraro, E. M. Trecarichi, B. Fiori, M. Rossi, R. Porta, K. de Gaetano Donati, M. La Sorda, T. Spanu, G. Fadda, R. Cauda, M. Sanguinetti, Biofilm Production by Candida Species and Inadequate Antifungal Therapy as Predictors of Mortality for Patients with Candidemia Journal of Clinical Microbiology. ,vol. 45, pp. 1843- 1850 ,(2007) , 10.1128/JCM.00131-07
Luc P. Brion, Smart E. Uko, David L. Goldman, Risk of resistance associated with fluconazole prophylaxis: systematic review. Journal of Infection. ,vol. 54, pp. 521- 529 ,(2007) , 10.1016/J.JINF.2006.11.017
Yan Li, Yukui Ma, Li Zhang, Feng Guo, Lei Ren, Rui Yang, Ying Li, Hongxiang Lou, In vivo inhibitory effect on the biofilm formation of Candida albicans by liverwort derived riccardin D. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0035543
Li-hua Yu, Xin Wei, Ming Ma, Xiao-jun Chen, Shuang-bo Xu, Possible Inhibitory Molecular Mechanism of Farnesol on the Development of Fluconazole Resistance in Candida albicans Biofilm Antimicrobial Agents and Chemotherapy. ,vol. 56, pp. 770- 775 ,(2012) , 10.1128/AAC.05290-11
Lorena S Derengowski, Calliandra De-Souza-Silva, Shélida V Braz, Thiago M Mello-De-Sousa, Sônia N Báo, Cynthia M Kyaw, Ildinete Silva-Pereira, Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis Annals of Clinical Microbiology and Antimicrobials. ,vol. 8, pp. 13- 13 ,(2009) , 10.1186/1476-0711-8-13