Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay.
作者： Masanori Sugiura , Tadashi Inagami , Valentina Kon
DOI: 10.1016/0006-291X(89)91372-7
关键词: Endocrinology 、 Endothelial stem cell 、 In vivo 、 Radioimmunoassay 、 EGTA 、 Biology 、 Internal medicine 、 In vitro 、 Endothelin receptor 、 Lactate dehydrogenase 、 Stimulation
摘要: Abstract A marked increase in immunoreactive endothelin was observed rat serum collected within 10–15 min after infusion of endotoxin. Endothelin level 117 ± 11.5 pg/ml (mean S.E., N=4) rats exposed to endotoxin as compared with undetectable levels (less than 2 pg/ml, controls. We have also a significant stimulation endothelin-release by from cultured bovine transformed thoractic aortic endothelial cells at concentrations ranging between 0.1 and 10.0 ug/ml. Serum indispensable for the stimulating effect endotoxin, although itself did not show any concentration used (1%). These results suggest that plays an important role mediation pathophysiological responses caused The were measured radioimmunoassay high sensitivity.
elsevier.com
sci-hub.se 参考文章(18)
Christine Schomisch Moravec, Elwood E. Reynolds, Robert W. Stewart, Meredith Bond, Endothelin is a positive inotropic agent in human and rat heart in vitro Biochemical and Biophysical Research Communications. ,vol. 159, pp. 14- 18 ,(1989) , 10.1016/0006-291X(89)92397-8
Peter D. Killworth, Adrian Edmund Gill (1937-1986) Nature. ,vol. 322, pp. 411- 411 ,(1986) , 10.1038/322411A0
B. O. Meyrick, U. S. Ryan, K. L. Brigham, Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants. American Journal of Pathology. ,vol. 122, pp. 140- 151 ,(1986)
W L Miller, M M Redfield, J C Burnett, Integrated cardiac, renal, and endocrine actions of endothelin. Journal of Clinical Investigation. ,vol. 83, pp. 317- 320 ,(1989) , 10.1172/JCI113876
T. Braun, E. Bober, S. Singh, D.P. Agarwal, H.W. Goededaa, Evidence for signal peptide at the aminoterminal end of human mitochondrail dehydrogenase FEBS Letters. ,vol. 233, pp. 440- 440 ,(1988) , 10.1016/0014-5793(88)80480-0
J.D. Firth, A.E.G. Raine, P.J. Ratcliffe, J.G.G. Ledingham, Endothelin: an important factor in acute renal failure? The Lancet. ,vol. 332, pp. 1179- 1182 ,(1988) , 10.1016/S0140-6736(88)90243-7
Vincent Lagente, Pierre Etienne Chabrier, Jean-Michel Mencia-Huerta, Pierre Braquet, Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig Biochemical and Biophysical Research Communications. ,vol. 158, pp. 625- 632 ,(1989) , 10.1016/0006-291X(89)92767-8
B.J.R. Whittle, J.V. Esplugues, Induction of rat gastric damage by the endothelium-derived peptide, endothelin. British Journal of Pharmacology. ,vol. 95, pp. 1011- 1013 ,(1988) , 10.1111/J.1476-5381.1988.TB11733.X
Yoshiyuki Uchida, H. Ninomiya, M. Saotome, A. Nomura, M. Ohtsuka, M. Yanagisawa, K. Goto, T. Masaki, S. Hasegawa, Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor European Journal of Pharmacology. ,vol. 154, pp. 227- 228 ,(1988) , 10.1016/0014-2999(88)90106-9
Carlo Alberto Maggi, Riccardo Patacchini, Sandro Giuliani, Alberto Meli, None, Potent contractile effect of endothelin in isolated guinea-pig airways. European Journal of Pharmacology. ,vol. 160, pp. 179- 182 ,(1989) , 10.1016/0014-2999(89)90670-5