Role of ornithine decarboxylase and the polyamines in nervous system development : a review

摘要: Abstract Development of nervous tissue is controlled, in part, by the ornithine decarboxylase (ODC)/polyamine system. Each brain region possesses a unique ontogenetic pattern for ODC, with highest levels enzyme associated periods most rapid growth. For this reason, perturbation ODC profile has proven useful examinations teratologic mechanisms and detection adverse environmental effects during development. More recently, replication neuronal cells developing been shown to require maintenance polyamine consequently, depletion polyamines α-difluoromethylornithine (DFMO, an inhibitor) arrests cell maturation. DFMO also interferes migration, axonogenesis synaptogenesis, leading disruption cytoarchitectural organization structures: these results imply similarly important role post-replicative events. Indeed, [3HDFMO-autoradiographic localization cerebellar lamina indicates high activity neuropil, areas axonal outgrowth, post-mitotic granule cells. Axonal outgrowth regeneration after nerve damage mature system may display some same characteristics as neurons, suggesting that two processes share common polyamine-dependent mechanisms.