Numerical chromosomal changes in DNA hypodiploid solid tumors: Restricted loss and gain of certain chromosomes

摘要: BACKGROUND DNA hypodiploidy is a unique and rare finding associated with aggressive behavior in solid tumors. Identifying the chromosomal changes underlying this feature may provide important information on development progression of these neoplasms. METHODS Fluorescence situ hybridization analysis using alpha-satellite probes for nine autosomes two sex chromosomes was performed interphase cells from 27 tumors which had been shown to be hypodiploid by flow cytometry. The abnormalities were correlated index tumor subtypes. RESULTS data show mutually exclusive loss certain compensatory gain other different net slightly more than tested. Polysomy chromosome 7 monosomy 17, X Y found most Significant differential 6,10, 12 among breast, kidney lung carcinomas noted. CONCLUSIONS Our study shows (i) 17 tumors, (ii) specific noted breast renal cell carcinomas, (iii) that mechanisms hyperdiploid exist.