Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping.
作者： Jane Bayani , Maria Zielenska , Paula Marrano , Yim Kwan Ng , Michael D. Taylor
DOI: 10.3171/JNS.2000.93.3.0437
关键词: Chromosome 7 (human) 、 Chromosome 17 (human) 、 Cytogenetics 、 Neuroectodermal tumor 、 Isochromosome 、 Comparative genomic hybridization 、 Primitive neuroectodermal tumor 、 Pathology 、 Biology 、 Fluorescence in situ hybridization
摘要: Object. Medulloblastomas and related primitive neuroectodermal tumors (PNETs) of the central nervous system are malignant, invasive embryonal with predominantly neuronal differentiation that comprise 20% pediatric brain tumors. Cytogenetic analysis has shown alterations in chromosome 17, particularly loss 17p formation isochromosome 17q, as well gain 7 most common changes among this group Comparative genomic hybridization (CGH) studies have largely confirmed these cytogenetic findings also identified novel regions gain, loss, amplification. The advent more sophisticated multicolored fluorescence situ (FISH) procedures such spectral karyotyping (SKY) now permits complete recognition all aberrations including extremely complex rearrangements. authors report a retrospective 19 medulloblastoma five PNET cases studied using combinations classic banding analysis, FISH, CGH, a...
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