Immunosenescence and germinal center reaction.
作者： Biao Zheng , Shuhua Han , Yoshimasa Takahashi , Garnett Kelsoe
DOI: 10.1111/J.1600-065X.1997.TB01028.X
关键词: T lymphocyte 、 Biology 、 Lymphokine 、 Germinal center 、 Lymphocyte 、 Endocrinology 、 Cellular immunity 、 Internal medicine 、 Immunology 、 Immune system 、 Immunosenescence 、 Lymphatic system
摘要: Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation immunocytes with reduced function and lymphocyte clones self-reactive potential. Coincidently, there is a profound reduction germinal center reaction aged. While this likely result age-associated impairment (e.g. diminished response to costimulus, altered lymphokine production etc.), centers may itself make an contribution further immunological dysfunction.
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