Immunologic mechanisms in UV-radiation carcinogenesis

摘要: Publisher Summary The chapter presents the new or altered antigens on cancer cells, tests of induction and antigenicity in immunosuppressed hosts, an examination immunosuppressive potency various carcinogens. These approaches have led to conclusion that, cancers associated with oncogenic viruses, immune system can play a decisive role both development subsequent growth. response is intimately involved case UV carcinogenesis because peculiar immunologic consequences exposure unusual antigenic characteristics resulting tumors. If only measure available induced by tumor its primary host, then one would conclude incorrectly that tumors were not antigenic. responses host be used define antigenicity. This provides illustration fact necessarily equivalent normal recipient transplanted syngeneic tumor. studies demonstrate regulatory pathways described for exogenous also control against tumor-specific transplantation (TSTA), even autochthonous host. An dictated some orderly way carcinogen has provided unique opportunity explore many facets complex relationship between developing system. It clear, at least this highly tumors, factors are as important pathogenesis initial transforming events. combination carcinogenic changes mediated radiation permitted observe extent carcinogen-induced capability mechanisms eliminate