Increased Appearance of Inducible Nitric Oxide Synthase in the Uterus and Embryo at Implantation
作者： Deeksha Saxena , Sharad B. Purohit , Pradeep Kumar G , Malini Laloraya
关键词: Endometrium 、 Endocrinology 、 Internal medicine 、 Nitric oxide synthase 、 Uterus 、 Blastocyst 、 Embryo 、 Estrogen 、 Immunocytochemistry 、 Biology 、 Nitric oxide
摘要: The aim of this study was to investigate the presence iNOS in murine uterus and embryo at implantation. Western blot analysis showed a 130-kDa band with strong reactivity anti-iNOS antibody pre- peri-implantation stage uteri. This faint postimplantation Immunocytochemical studies heavy localization specifically on apical cells uterine endometrium stages. But uteri resorbed showing weaker expression iNOS. induced by estrogen induction intensified when progesterone given along estrogen. truly mimics vivo situation since implantation mice occurs an surge background progesterone. embryos too express stage. We suggest that expressed would lead enhanced NO production, which could act as vasodilator angiogenic mediator. These effects promote attachment blastocyst uterus.
elsevier.com
cabdirect.org
sci-hub.se 参考文章(46)
Malini Laloraya, G Pradeep kumrr, Manmohan M. Laloraya, A possible role of superoxide anion radical in the process of blastocyst implantation in Musmusculus Biochemical and Biophysical Research Communications. ,vol. 161, pp. 762- 770 ,(1989) , 10.1016/0006-291X(89)92665-X
C. H. Evans, Nitric oxide: what role does it play in inflammation and tissue destruction? Agents and actions. ,vol. 47, pp. 107- 116 ,(1995) , 10.1007/978-3-0348-7343-7_9
H Rubbo, R Radi, M Trujillo, R Telleri, B Kalyanaraman, S Barnes, M Kirk, B A Freeman, Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. Journal of Biological Chemistry. ,vol. 269, pp. 26066- 26075 ,(1994) , 10.1016/S0021-9258(18)47160-8
Asif Ahmed, Sharon Dearn, Munjiba Shams, Xiao F. Li, Rajbant K. Sangha, Marek Rola‐Pleszczynski, Jianqiao Jiang, Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125 The FASEB Journal. ,vol. 12, pp. 831- 843 ,(1998) , 10.1096/FASEBJ.12.10.831
M.A. Marletta, Nitric oxide synthase structure and mechanism. Journal of Biological Chemistry. ,vol. 268, pp. 12231- 12234 ,(1993) , 10.1016/S0021-9258(18)31375-9
R G Knowles, S Moncada, Nitric oxide synthases in mammals. Biochemical Journal. ,vol. 298, pp. 249- 258 ,(1994) , 10.1042/BJ2980249
Stephen M. Sladek, Anne C. Regenstein, David Lykins, James M. Roberts, Nitric oxide synthase activity in pregnant rabbit uterus decreases on the last day of pregnancy American Journal of Obstetrics and Gynecology. ,vol. 169, pp. 1285- 1291 ,(1993) , 10.1016/0002-9378(93)90295-T
V. Novaro, E. González, A. Jawerbaum, V. Rettori, G. Canteros, M. F. Gimeno, Nitric oxide synthase regulation during embryonic implantation. Reproduction, Fertility and Development. ,vol. 9, pp. 557- 564 ,(1997) , 10.1071/R97005
D. Taskiran, M. Stefanovicracic, H. Georgescu, C. Evans, Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1 Biochemical and Biophysical Research Communications. ,vol. 200, pp. 142- 148 ,(1994) , 10.1006/BBRC.1994.1426
U. Schaefer, A. Schneider, D. Rixen, E. Neugebauer, Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes Inflammation Research. ,vol. 47, pp. 256- 264 ,(1998) , 10.1007/S000110050327