Synergistic Effect of Prochlorperazine and Dipyridamole on the Cellular Retention and Cytotoxicity of Doxorubicin
作者： Awtar Krishan , Wilfred D. Stein , Hugo Fernandez , Kasi S. Sridhar , Yang Ping Hu
DOI:
关键词: Verapamil 、 Doxorubicin 、 Daunorubicin 、 Drug interaction 、 Dipyridamole 、 Pharmacology 、 In vivo 、 Prochlorperazine 、 Pharmacokinetics 、 Medicine
摘要: Incubation of drug-resistant human tumor cells with a combination prochlorperazine and dipyridamole has additive/synergistic effect on the cellular retention cytotoxicity doxorubicin. In patients administered fixed dose doxorubicin escalating doses dipyridamole, mean plasma levels achieved were as high 3.01 +/- 0.41 microm 0.94 0.09 microm, respectively. Plasma samples from analyzed in an vitro assay to monitor tritium-labeled daunorubicin MDR1-transfected P388 cells. 22 49 analyzed, efflux blocking activity was one-half or greater than that incubated 12.5 microM verapamil, well-known blocker. These observations suggest may enhance by while reducing normal tissue toxicity unwanted side effects vivo.
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