Porous ongrowth surfaces alter osteoblast maturation and mineralization.

摘要: Implant fixation through osseointegration is essential for the success of uncemented total joint arthroplasty, and nature composition implant surface play a critical role in this process. Despite widespread use implants, extent bone ingrowth into implants generally only small percentage surface. An understanding processes whereby cells grow multiply on porous surfaces design manufacture that maximize fixation. A wide variety materials are currently utilized including titanium mesh, cobalt chromium beads, tantalum deposited carbon network. differences physical chemical properties these materials, all have functioned well clinically. Therefore, goals study were to compare contrast effects proliferation, phenotypic maturation, mineralization osteoblasts. Disks tantalum, beaded fabricated processed employing same methods used produce packaging sterilization. Preosteoblasts plated disks, cellular morphology was evaluated by scanning electron microscopy. Osteoblast proliferation significantly higher compared other surfaces. Alkaline phosphatase activity, osteocalcin secretion, upregulation RUNX2 inversely proportional rate proliferation. Mineralization osteoblasts paralleled These findings suggest interstices along with delayed maturation favorable increased ongrowth ultimately stabilization. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 276–281, 2015.