Intense pulsed light photorejuvenation: a histological and immunohistochemical evaluation.

摘要: BACKGROUND The use of intense pulsed light (IPL) for facial rejuvenation had been the topic many studies. However, few them discussed quantitative changes in extracellular matrix proteins after IPL therapy. OBJECTIVE To objectively quantify histological treatment wrinkles. METHODS Biopsy specimens were obtained from periocular area six volunteers Fitzpatrick skin type III-IV and Glogau's class I-III They subjected to three months (six sessions at two-week intervals). Using immunostaining analysis coupled with computerized morphometric analysis, evaluation collagen types I, III VII, newly synthesized collagen, total elastin tropoelastin was performed biopsies baseline, end treatment, post-treatment. RESULTS Clinical assessment did not show clinically noticeable improvement wrinkles treatment. Furthermore, showed no statistically significant (P>0.05) response CONCLUSION Although 50 percent mild texture none reported tightening or No observed post