Microneedling: Matching the results of medical needling and repetitive treatments to maximize potential for skin regeneration
作者： S. Zeitter , Z. Sikora , S. Jahn , F. Stahl , S. Strauß
DOI: 10.1016/J.BURNS.2013.12.008
关键词:
摘要: The benefits and risks of singular repetitive microneedling (1 mm) have not been thoroughly investigated. aim this study was to evaluate the skin needling with a device in an animal model without skincare. 30 Sprague Dawley rats were randomized five groups: control, skin-care only (Vitamin A & C), 1× 1 mm, 4× mm skin-care. All animals euthanized after 10 weeks. Skin specimens stained HE Masson's trichrome. Additionally, gene expression analysis microarray technique for various growth factors (TGFβ1-3, FGF, EGF, VEGF, TNF-α) real time reverse transcription PCR collagen I III conducted. We showed that matches sessions superposition epidermal dermal such as increase thickness (up 658% increase, p value 0.0008) connective tissue--even more so when combined vitamin C. Juvenile itself up-regulated all groups, while down-regulated. Singular PCI can achieve supersede results already shown medical needling.
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