Plasma long pentraxin 3 as a marker of endothelial dysfunction in early diabetic nephropathy

作者: Elham M. Yousief , Amr A. El Meligi , Manal A. Aziz , Hemmat E. El Haddadd , Marian F. Ishak

DOI: 10.7123/01.EJIM.0000433328.59695.F9

关键词: Type 2 diabetesEndocrinologyMedicineInternal medicineDiabetic nephropathyDiabetes mellitusGastroenterologyNephropathyMicroalbuminuriaEndothelial dysfunctionPTX3Von Willebrand factor

摘要: Objective This study investigated the utility of measuring plasma long pentraxin 3 (PTX3) levels in early detection endothelial dysfunction compared with Von Willebrand factor (vWF) activity and flow-dependent arterial dilatation (well-known markers dysfunction) diabetic nephropathy. Materials methods A total 50 Egyptian patients type 2 diabetes 20 healthy controls were recruited from Diabetes, Endocrinology Metabolism center, Faculty Medicine, Cairo University. The divided into two equal groups comparable age sex: group I consisted normal urinary albumin excretion II microalbuminuria. Results In II, PTX3 level was significantly higher (median value 2.3 ng/ml) mean flow-mediated (FMD; 0.433±0.059) lower when control (PTX3 1.15 ng/ml, FMD 0.901±0.04; P Conclusion may represent a useful marker

参考文章(42)
Jef Emeis, Henk Bilo, Coen Stehouwer, Claus Thomsen, Ole Rasmussen, Kjeld Hermansen, Claes Wollheim, Jørgen Ingerslev, Ulrich Vischer, von Willebrand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf:AgII). Thrombosis and Haemostasis. ,vol. 80, pp. 1002- 1007 ,(1998) , 10.1055/S-0037-1615401
Donald W. Cockcroft, Henry Gault, Prediction of Creatinine Clearance from Serum Creatinine Nephron. ,vol. 16, pp. 31- 41 ,(1976) , 10.1159/000180580
J Calles-Escandon, D Ballor, J Harvey-Berino, P Ades, R Tracy, B Sobel, Amelioration of the inhibition of fibrinolysis in elderly, obese subjects by moderate energy intake restriction. The American Journal of Clinical Nutrition. ,vol. 64, pp. 7- 11 ,(1996) , 10.1093/AJCN/64.1.7
JAN J. SIXMA, PHILIP G. de GROOT, Von Willebrand Factor and the Blood Vessel Wall Mayo Clinic Proceedings. ,vol. 66, pp. 628- 633 ,(1991) , 10.1016/S0025-6196(12)60523-0
Anna Witasp, Mikael Rydén, Juan Jesús Carrero, Abdul Rashid Qureshi, Louise Nordfors, Erik Näslund, Folke Hammarqvist, Samsul Arefin, Karolina Kublickiene, Peter Stenvinkel, Elevated Circulating Levels and Tissue Expression of Pentraxin 3 in Uremia: A Reflection of Endothelial Dysfunction PLoS ONE. ,vol. 8, pp. e63493- ,(2013) , 10.1371/JOURNAL.PONE.0063493
Lorenzo Ghiadoni, Daniele Versari, Armando Magagna, Isabella Kardasz, Yvonne Plantinga, Chiara Giannarelli, Stefano Taddei, Antonio Salvetti, Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients. Journal of Hypertension. ,vol. 25, pp. 361- 366 ,(2007) , 10.1097/HJH.0B013E3280115901
M T Johnstone, S J Creager, K M Scales, J A Cusco, B K Lee, M A Creager, Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. ,vol. 88, pp. 2510- 2516 ,(1993) , 10.1161/01.CIR.88.6.2510
Wayne A. Border, Tatsuo Yamamoto, Nancy A. Noble, Transforming Growth Factor β in Diabetic Nephropathy Diabetes \/ Metabolism Reviews. ,vol. 12, pp. 309- 339 ,(1996) , 10.1002/(SICI)1099-0895(199612)12:4<309::AID-DMR172>3.0.CO;2-A