Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

摘要: In order to quantitatively investigate the importance of transfollicular pathway for drug delivery, penetration through human scalp skin was investigated using liquid formulations containing lipophilic and hydrophilic drugs in vitro. The examined fluorescent probes. Additionally, compared with that via abdominal clarify usefulness intrafollicular delivery. Lipophilic melatonin (MT) ketoprofen (KP) showed high permeabilities skin, although flux KP much higher. Absorption enhancers, N-methyl-2-pyrrolidone isopropylmyristate, only slightly increased fluxes. Hydrophilic fluorouracil (5FU) acyclovir (ACV) penetrated relatively large However, there variability fluxes these across from different sources. When relationship between hair follicle density estimated, good correlation two (r = 0.651 MT r 0.666 ACV, P < 0.05). histologic examination following application formulation nile red or sodium fluorescein, indicated probes permeated into junction internal external root sheath follicles diffused dermis outer at initial times. red, a probe, stratum corneum later than follicles. permeation 5FU higher being 27 48 times as respectively. These results indicate delivery will offer an available means drugs, particularly drugs.