The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

作者: Dimitris Thanos , Tom Maniatis

DOI: 10.1016/0092-8674(92)90554-P

关键词: GeneInterferonAT-hookMolecular biologyTranscription factorRegulatory sequenceSendai virusHigh-mobility groupBiologyHMGA1

摘要: In this paper, we show that both NF-κB and the high mobility group protein I(Y) (HMG I(Y)) are required for virus induction of the human interferon-β (IFN-β) gene. NF-κB binds to the …

参考文章(58)
M.B. Urban, R. Schreck, P.A. Baeuerle, NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. The EMBO Journal. ,vol. 10, pp. 1817- 1825 ,(1991) , 10.1002/J.1460-2075.1991.TB07707.X
L.F. Reis, H. Harada, J.D. Wolchok, T. Taniguchi, J. Vilcek, Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. The EMBO Journal. ,vol. 11, pp. 185- 193 ,(1992) , 10.1002/J.1460-2075.1992.TB05041.X
Steven Henikoff, Unidirectional digestion with exonuclease III in DNA sequence analysis. Methods in Enzymology. ,vol. 155, pp. 156- 165 ,(1987) , 10.1016/0076-6879(87)55014-5
J Hiscott, D Alper, L Cohen, J F Leblanc, L Sportza, A Wong, S Xanthoudakis, Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer. Journal of Virology. ,vol. 63, pp. 2557- 2566 ,(1989) , 10.1128/JVI.63.6.2557-2566.1989
K R Johnson, D A Lehn, T S Elton, P J Barr, R Reeves, Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). Journal of Biological Chemistry. ,vol. 263, pp. 18338- 18342 ,(1988) , 10.1016/S0021-9258(19)81364-9
E. M. DeMaeyer, Jaqueline De Maeyer-Guignard, Interferons and other regulatory cytokines Wiley. ,(1988)