Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
作者： Satoru Tanabe , Nancy J. Zeleznik-Le , Hirofumi Kobayashi , Christine Vignon , Rafael Espinosa
DOI: 10.1002/(SICI)1098-2264(199604)15:4<206::AID-GCC2>3.0.CO;2-5
关键词: Chromosomal translocation 、 Myeloid leukemia 、 Breakpoint 、 Molecular biology 、 Leukemia 、 Biology 、 Primer (molecular biology) 、 Complementary DNA 、 Translocation Breakpoint 、 Gene
摘要: The t(6;11)(q27;q23) is one of the most common translocations observed in patients with acute myeloid leukemia (AML). translocation breakpoint involves MLL gene, which human homolog Drosophila trithorax at 11q23 and AF6 gene 6q27. Reverse transcriptase-polymerase chain reaction (RT-PCR) using an sense primer antisense detected MLL/AF6 fusion cDNA from three t(6;11) [two AML T-acute lymphoblastic (ALL)] cell line. point these cases identical, regardless phenotype. ML-2 line, was established a patient that developed after complete remission T-cell lymphoma, has retained 11q23–24 deletion lymphoma stage acquired development AML. cells have no normal on Southern blot analysis, indicates intact not necessary for survival leukemic cells. Genes Chromosom Cancer 15:206–216 (1996). © 1996 Wiley-Liss, Inc.
sci-hub.se 参考文章(40)
J Pedersen-Bjergaard, JD Rowley, The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation Blood. ,vol. 83, pp. 2780- 2786 ,(1994) , 10.1182/BLOOD.V83.10.2780.2780
Harbott J, Brettreich S, Borkhardt A, Repp R, Kreuder J, Nishida K, Haupt E, Hammermann J, Lampert F, Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia. ,vol. 9, pp. 210- 215 ,(1995)
T Chaplin, P Ayton, OA Bernard, V Saha, V Della Valle, J Hillion, A Gregorini, D Lillington, R Berger, BD Young, A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia Blood. ,vol. 85, pp. 1435- 1441 ,(1995) , 10.1182/BLOOD.V85.6.1435.BLOODJOURNAL8561435
Yamamoto K, Iida S, Komatsu H, Takahashi T, Akao Y, Kodera Y, Seto M, Ariyoshi Y, Nakazawa S, Kojima S, Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. Oncogene. ,vol. 8, pp. 2617- 2625 ,(1993)
S Kobayashi, M Teramura, I Sugawara, K Oshimi, H Mizoguchi, Interleukin-11 Acts as an Autocrine Growth Factor for Human Megakaryoblastic Cell Lines Blood. ,vol. 81, pp. 889- 893 ,(1993) , 10.1182/BLOOD.V81.4.889.889
HJ Super, NR McCabe, MJ Thirman, RA Larson, MM Le Beau, J Pedersen-Bjergaard, P Philip, MO Diaz, JD Rowley, Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II Blood. ,vol. 82, pp. 3705- 3711 ,(1993) , 10.1182/BLOOD.V82.12.3705.3705
John H. Kersey, Joanne M. Hilden, Chien-Shing Chen, Joy Frestedt, Roderick Moore, Heterogeneity in MLL/AF-4 Fusion Messenger RNA Detected by the Polymerase Chain Reaction in t(4;11) Acute Leukemia Cancer Research. ,vol. 53, pp. 3853- 3856 ,(1993)
J Morrissey, DC Tkachuk, A Milatovich, U Francke, M Link, ML Cleary, A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias Blood. ,vol. 81, pp. 1124- 1131 ,(1993) , 10.1182/BLOOD.V81.5.1124.1124
N. R. McCabe, R. C. Burnett, H. J. Gill, M. J. Thirman, D. Mbangkollo, M. Kipiniak, E. van Melle, S. Ziemin-van der Poel, J. D. Rowley, M. O. Diaz, Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 11794- 11798 ,(1992) , 10.1073/PNAS.89.24.11794
J. Corral, A. Forster, S. Thompson, F. Lampert, Y. Kaneko, R. Slater, W. G. Kroes, C. E. van der Schoot, W. D. Ludwig, A. Karpas, Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 8538- 8542 ,(1993) , 10.1073/PNAS.90.18.8538