NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression.
作者： Qiqi Wang , Qiong Qin , Ran Song , Chunjuan Zhao , Hua Liu
DOI: 10.1038/S41419-018-0711-X
关键词: Gene expression 、 Signal transduction 、 Downregulation and upregulation 、 Wnt signaling pathway 、 Cervical cancer 、 Cell growth 、 Cancer research 、 Cancer 、 Beta-catenin 、 Medicine
摘要: Cervical cancer is one of the most lethal types in female. Aberrant activation Wnt/β-catenin signaling pathway has been found to be involved cervical development and progression, whereas underlying molecular mechanisms remain poorly understood. The present study showed that NHERF1 was a novel gene associated with both cell proliferation Wnt by analysis differential expression cluster for specimens from GEO data sets. It further demonstrated cellular inhibition through dependent on α-actinin-4 (ACTN4) expression. A negative association between levels ACTN4 β-catenin mouse xenograft model specimens. Low were associate set enrichment analysis, also an independent predictive factor worse prognosis patients Cox regression analysis. These findings demonstrate inhibits signaling-mediated via suppression ACTN4, downregulation may contribute progression cancer. shed some lights understanding cisplatin resistance HPV-inactive patients.
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